Savor Health

Humans need sugar, but not too much!

Sugar is sweet, full of calories, and a very simple form of a carbohydrate that is quite easily digested and used efficiently by the body for it’s important metabolic needs.  Too much, however, is unnecessary.  Yet in todays world, getting too much is becoming too easy. 

Sugar is hidden within numerous packaged food products to promote shelf life and increase the bliss felt after eating something so sweet.  Sugar is delicious.  From an evolutionary perspective, we have an innate taste for sugar, that proves full of pleasure.  At times of famine, this calorie rich nutrient was essential for survival, and due to our biological makeup, we still feel this need.  Sugar causes the chemical called dopamine to be released in the brain and can be addictive. 

Maintaining normal blood sugar levels is critical for muscular energy and to sustain a healthy brain.  If you are active, having a good supply of stored energy, called glycogen, is important for the muscles to tap into.  Sugar makes up this energy supply within our skeletal muscles and liver.  When it’s depleted, our bodies will find alternate pathways to create sugar through the breakdown of our own fats and proteins in our muscles.  To prevent this, eating carbs are necessary.

 

Simple or Complex?

Carbohydrates come in two “flavors”: simple and complex.

Simple carbohydrates are found in foods like white rice, cookies, and candies. They tend to have a sweeter taste and are rapidly absorbed into the bloodstream after being consumed, causing sharp spikes in insulin.  They are best eaten in moderation, or just prior to moderate to intense work outs lasting longer than 30 minutes.

Complex carbohydrates include whole grains, vegetables, and fruits, and they are higher in fiber, take longer to digest, and include vitamins and minerals essential to your overall health.  Insulin spikes are slower and steadier due to the progressive absorption by the intestines.  The essential fibers help to feed the healthy bacteria in the large intestine, and promote satiety to help avoid excessive calorie intake.  These should constitute the majority of the 45-60% of carbohydrates that are eaten per day within a persons caloric needs.  

 

The research behind cancer and sugar

When it comes to the possible relationship between sugar and cancer, the research is interesting.  Population based studies have shown that people with the highest sugar consumption have the highest prevalence of cancer.  But is there more to this?

Since sugar is calorically dense and can easily cause weight gain, and obesity is correlated with cancer due to a myriad of reasons that include increased systemic inflammation, there could be a possible link as a result[i].

Researchers have been investigating several mechanisms that may uncover a potential connection behind sugar and cancer.  Lets explore some of the more promising theories.

 

AGEing

One of the relationships between sugar and cancer has to do with Advanced Glycation End Products or AGES. AGES are highly unstable molecules. They are linked to oxidation and inflammation, creating unstable cellular environments, possibly conducive to the propagation of cancer cells.  We all form AGES as a normal part of aging, but since simple sugars serve as the backbone of AGE molecules, people who consume more simple sugars in their diets may have higher rates of AGE formation.  

 

Insulin resistance

When a cell is insulin resistant, the insulin transporter does not work to allow insulin to latch onto a cell to transport sugar from the blood into storage.  Thus, glucose remains in the blood, driving the body to release even more insulin. This is insulin resistance, and it’s this propogation that is detrimental to health, and leads to diabetes, and now perhaps cancer. 

Insulin resistance has a number of inflammatory implications in the body which include high levels of growth factors, adipokines, and reactive oxygen species that are ultimately creating a pro-inflammatory state associated with the initiation and proliferation of cancer cells.

 

Cancers Possibly Associated with Sugar

  1. Breast Cancer – In the case of breast cancer, the relationship seems to manifest through hormonal changes. There only seems to be a relationship with estrogen receptor-positive breast cancer.  Insulin and insulin growth factor-1 (IGF-1) associated with sugar intake lead to elevated levels of estrogen and other hormones that may contribute to tumor progression. Once diagnosed, insulin resistance may lead to a worse prognosis and a more challenging journey.  Since genetics in large part determines the risk for breast cancer, those who are genetically inclined and tend to have more IGF -1 in the blood may be at the greatest risk.
  2. Pancreatic cancer – It is unknown if insulin resistance causes pancreatic cancer, or vice versa.  A 2017 review article determined that diabetes increased risk of pancreatic cancer[ii].
  3. Lung, liver, and endometrial cancer – Recently, a certain common tumor type of lung cancer called squamous cell carcinoma has been shown to be made up of high levels of GLUT1 receptors, which have a vital connection to sugar!  Glut 1 is a main transporter of glucose into the cell, essentially the gatekeeper that allows sugar to enter.  It was discovered that these particular tumor types can survive and grow more readily, within a healthy environment of sugar, essentially feeding on the sweet stuff as it’s available.  This finding leads the researchers to assume that a lower sugar diet will help to slow the progression of this tumor, and may in fact have a direct association with sugar[iii].  

 

Take Home Advice

Research continues to solve the riddle of cancer, and in the case of sugar, we know too much is bad for your health, but the direct cause of cancer by sugar is still under investigation and no sincere claims can be made just yet.  However, the research is compelling, and it may be in the best interest to limit your sugar intake. 

Keep it complex! Focus your intake on the nutrient rich complex carbohydrates that include whole grains, fruits, vegetables and beans and legumes.  And if you will be having sweet treats, cereal or any other more simple form of carbohydrate, take control of your health and eat them strategically.  Consume in the beginning of the day or prior to more intense workouts, so that your body can use the sugar as fuel instead of storing it as sugar and spiking that insulin unnecessarily high.

And focus on the label.  Since the new and improved nutrition facts label is rolling into the market, the “added sugars” will be listed as a subcategory of “sugars” which will help to clarify which type of sugar is most prevalent in the food you are eating.  Keep total added sugars around 50grams or less for the day, which turns out to be about 10% or less of your total calories.  

 

References
[i] Zheng Y, Manson JE, Yuan C, et al. Associations of weight gain from early to middle adulthood with major health outcomes later in life. JAMA. 2017;318(3):255-269
[ii] Shafqet M., Sharzehi K. Diabetes and the Pancreatobiliary Diseases. (2017) Curr Treat Options Gastroenterol. 15(4): 508-519
[iii] Goodwin, J; Neugent ML et al. The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition. (2017). Nat Commun. 8:15503

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  1. Thanks for the feedback! It is a really interesting topic that I think we learn more about through further research as time elapses.

  2. Thank you so much for your feedback and feel free to let me know if there are any other topics you’d like to read more about. Happy thanksgiving!!

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Susan started Savor Health after losing a close friend to a brain tumor and, through that experience, becoming aware of the significant unmet nutritional needs of people with cancer.  Struck by the fact that her friend was told “nutrition doesn’t matter” and “eat whatever you want,” Susan read the evidence-based literature on the subject, interviewed oncologists, oncology nurses and oncology dietitians, as well as patients and caregivers, and found that, in fact, nutrition does matter in oncology. Armed with solid scientific evidence supporting the clinical and quality of life benefits of proper nutrition, Susan left Wall Street and created Savor Health, an AI-based provider of personalized and clinically appropriate nutrition solutions for cancer patients, their caregivers and health enterprises. Susan brings to Savor Health over 25 years of industry experience in healthcare and business as well as expertise in strategy, finance and management.

Susan is an outspoken and tireless advocate for cancer patients receiving proper nutrition and nutrition support before, during and after treatment. She strongly believes that the U. S. healthcare system requires new innovation to transform it into a more holistic and integrated system of care whereby multiple disciplines coordinate care together for the benefit of the whole patient. As part of this, her goal is for nutrition to be an integral component of such an integrated cancer care delivery system.  Susan’s commitment to the field of oncology extends beyond Savor Health to volunteer work at Memorial Sloan Kettering Cancer Center in pediatrics and as a runner for Fred’s Team to raise money for research at Memorial Sloan Kettering. Susan participated in the Cancer Moonshot in June of 2016 where she was a breakout session group “igniter” tasked with starting and leading discussion. Susan’s first book, the Meals to Heal Cancer Cookbook, was published in March 2016.

In addition to her role as CEO of Savor Health, Susan speaks nationally about the importance of ensuring proper nutrition in the cancer patient and on topics including leadership and startups. She has been a speaker at the Harvard Medical School’s Career Advancement and Leadership Skills for Women in Healthcare, ESMO World Congress on GI Cancer, BioPharm America, AARP Live @50+, Lake Nona Impact Forum, and IIR ePharma Summit.

Prior to starting Savor Health, Susan had a successful career on Wall Street as a healthcare services investment banker working at prestigious firms including Donaldson, Lufkin & Jenrette, Wasserstein Perella and Robertson Stephens. Susan earned a B.A. from Duke University and M.B.A. from the University of Virginia’s Darden Graduate School of Business.

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Marissa Buchan is a registered dietitian, with advanced practice certifications in Oncology Nutrition (CSO) and Clinical Research (CCRP). She received her Bachelor’s degree in Psychology from Duke University, and Master’s of Science degree in Clinical Nutrition from New York University. Marissa worked for 10 years at Memorial Sloan Kettering Cancer Center in both the clinical research and nutrition departments.  In addition to counseling patients before, during, and after cancer therapy, she spearheaded nutrition-research efforts for the bone marrow transplant service. She has co-authored over 20 articles and has a particular interest in the role of nutrition on the intestinal microbiota and its impact on patient outcomes. When Marissa’s not wearing her lab coat, she’s in her apron whipping up healthy and delicious recipes that you can find on her blog, Get Off Your Tush and Cook.

Marissa is Chief Operating Officer of Savor Health where she leads operations working with the technology, clinical, and business development teams and management. Prior to assuming the role of COO in March 2020, Marissa was Vice President, Clinical Research and Operations at Savor Health where she worked closely with Savor Health’s Chief Medical Advisor, Scientific Advisory Board, and Clinical Operations Team to evaluate, design and conduct clinical research.  She also counsels patients on oncology nutrition issues and contributes to the Company website’s clinical content.

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Dr. DeFrance has a unique background including clinical interventional cardiologist, chief medical officer, educator, outcomes researcher and entrepreneur. He has expertise in Lifestyle medicine in which he was board certified in 2020 and is highly interested in the prevention and reversal of chronic disease. Dr. DeFrance also has expertise in appropriate utilization of technology in medicine, healthcare economics, value-based metrics, and educational design and delivery. He worked as Chief Medical Officer for HealthHelp, one of the largest specialty benefit managers in the US, and led large teams of healthcare professionals in writing evidence based appropriate care guidelines and rule sets which improve the quality and safety of medicine for over 20 million people in the US while also creating sustained savings in healthcare. He has also designed clinical decision support systems that are currently in use helping to improve patient care.

In 2018 Dr. DeFrance founded MedMentor Education, a company that provides state of the art CME content using the latest in eLearning science and online delivery platforms. Dr. DeFrance is also the founder and President of Digimedica, a consulting and educational design and delivery company for healthcare professionals, hospitals, and universities. He is passionate about creating systems to optimize knowledge transfer and has won numerous awards for teaching excellence during his career. He is an expert in cardiovascular CT imaging and has taught more than 3,000 physicians how to perform and interpret cardiac CT nationally and internationally and has lectured extensively on this subject.

Dr. DeFrance has a stellar reputation in the medical field and continues work to improve the quality and safety of patient care in the US.

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Alyson is a registered nurse and is certified in oncology nursing (OCN) through the Oncology Nursing Society (ONS). She also has her certification as an ONS Biotherapy and Chemotherapy Provider. Alyson studied nursing at Thomas Jefferson University where she obtained her Bachelor’s of Science in Nursing (BSN). Since starting her nursing career in 2004, Alyson has had a strong dedication and commitment to oncology patients. She has worked inpatient specializing in Bone Marrow and Peripheral Blood Stem Cell Transplantation. Alyson currently works in outpatient oncology at the North Shore-LIJ Monter Cancer Center. Alyson is part of the clinical team at Savor Health where she counsels patients on oncology and oncology nutrition issues and contributes to website and other Savor Health content.

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Chelsey is a Registered Dietitian and Board Certified Specialist in Oncology nutrition (CSO). She completed her Dietetic Internship at Northwell Health, received her BS in Dietetics at the University of Wisconsin-Madison, and her MS in Nutrition at Stony Brook University’s School of Medicine. Chelsey works as an outpatient dietitian at Mount Sinai covering all of the downtown cancer services at Mount Sinai Beth Israel and Philips Ambulatory Care Center. Chelsey works with patients and families before, during and after treatment to optimize their nutrition through dietary counseling and support. Chelsey has experience counseling clients with a variety of diagnoses including breast cancer, lung cancer, prostate cancer, head & neck cancer, and more. Chelsey also enjoys sharing nutrition knowledge with her peers by running a monthly Employee Wellness program that showcases healthy topics, recipes and food demos.

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Michelle is a Registered Dietitian specializing in oncology. She works as a clinical dietitian at an ambulatory cancer center in New York City and is a consultant for Savor Health. She is passionate about educating oncology patients on the importance of nutrition during their fight against cancer and helping them to optimize their nutrition through all phases of treatment. Michelle received her Bachelor of Science degree in dietetics from the University of Wisconsin-Madison and her Master of Science degree in Clinical Nutrition from New York University.

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Denise Sievering is a Registered Dietitian who is board certified in Oncology Nutrition as well as Nutrition Support. A fluent Spanish speaker, Denise joined the Savor Health team to support Spanish speaking cancer patients and to continue to expand the Platform’s nutritional strategies and recommendations in Spanish. Denise holds a Bachelor of Science degree from Rutgers University, and completed her internship at New York Presbyterian Hospital (NYP). Denise started her career as a registered dietitian at NYP-Columbia University Medical Center, primarily covering inpatient Oncology units. Denise also holds a Master of Arts degree in Mental Health Counseling from New York University, and incorporates her advanced training in motivational interviewing and empathic listening in her patient encounters, particularly those whose lives have been forever changed by a cancer diagnosis. A New Jersey native, Denise now resides in sunny San Diego, CA where she works as a part-time outpatient Oncology dietitian at Scripps Health-MD Anderson Cancer Center, and also works as an inpatient dietitian at Kaiser Permanente. In her spare time, Denise can be found at a mom-and-pop taco shop, one of the many local craft breweries, and exploring her new city of San Diego with her husband and her rescue pup, Ripley.

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Karen is a Registered Dietitian, Board Certified Specialist in Oncology Nutrition and registered in New York as a Certified Dietitian Nutritionist. Fluent in Spanish, Karen joined the Savor Health team to support Spanish speaking cancer patients and to continue to expand the Platform’s nutritional strategies and recommendations in Spanish. Karen received her Bachelor of Science degree from Ithaca College and her Master of Science degree from Hunter College. She works as an outpatient oncology dietitian in New York. Karen often works with local community centers to host nutrition programs for cancer survivors and their families, leading classes on how to live healthier lifestyles throughout their continuum of care. The American Institute of Cancer Research selected to showcase one of her many programs at their conference in 2019. Karen has written for and lent commentary to various publications and truly enjoys teaching people how to eat better. She loves to cook and strongly feels that healthy food doesn’t have to taste bad.

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Allie is a Registered Dietitian and a Certified Specialist in Oncology (CSO). She joins Savor in 2023, bringing years of experience from the John Theurer Cancer Center in New Jersey, where she worked with patients with a variety of cancers. Her goal is to help people feel their best, both mentally and physically, when physical health challenges arise. She believes in the power of nutrition ever since the impact it made on her athletic career as a volleyball player during college. Allie graduated with her Bachelor of Science degree from University of Maryland-Baltimore County and has her Master’s degree in Human Nutrition from the University of Wisconsin Stout. She enjoys travelling, enjoying different cuisines, cooking, and hiking and other outdoor activities with her family and dog.

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Julia Penberg is a seasoned healthcare professional with more than 30 years of experience focusing on maximizing operational excellence, leading clinical program development and building strong cross-functional teams. Her previous roles include overseeing the performance of clinical managers and nurse practitioners across multiple markets within United Healthcare-Optum’s Medicare Advantage and dual-eligible special needs populations, payer outreach and program development at Mayo Clinic, ground level specialty hospital development and direct patient care as a family and dermatology nurse practitioner. Julia volunteered as an operating room nurse and nurse practitioner on several mission trips to Romania and was a support group leader for the Kansas City chapter of the International Myeloma Foundation. Her motivation throughout her career has been with wellness promotion, disease risk modification and ensuring the best patient experience across the health continuum. Ms. Penberg received an MBA from the University of Dallas; a MS in Nursing from the University of Kansas and a BS in Nursing from the University of Texas-Austin. She is board certified as a Family Nurse Practitioner.

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Rachel is a Registered Dietitian and Board Certified Specialist in Oncology Nutrition (“CSO”). She joined NYP-Columbia as the outpatient oncology dietitian in 2020 after working at Jamaica Hospital Medical Center for two years. Rachel completed her dietetic internship through Keene State College in 2017. She is pursuing an MS in Integrative Nutrition at Stony Brook University and has a BS in Human Nutrition, Foods and Exercise from Virginia Tech. Rachel provides nutrition counseling to all types of oncology patients and helps them understand the mental and physical benefits of nutrition as an ally in their fight against cancer. In her free time she enjoys slow meals with family and friends, Pilates, and tending to her fire escape garden.

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Allie Werner is a Registered Dietitian at Fresenius Kidney Care where she provides medical nutrition therapy diet counseling to patients on Dialysis. She received her Bachelor’s Degree in nutrition from Indiana University and completed her Master’s Degree and dietetic internship at Loyola University Chicago. In her free time she enjoys spending time with friends and family, checking out the amazing food scene in downtown Chicago, and exercising on her Peloton bike.

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Immersed in the tech world for a decade, I've coded, led teams, and honed my skills in architecture and design. As a tech enthusiast, I've seamlessly woven through full-stack projects, fusing my love for code with the art of leadership.

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Mohit is a full-stack developer with expertise in Python and JavaScript, known for his efficient coding and ability to deliver scalable software solutions. His technical contributions are highlighted on GitHub and Stack Overflow, demonstrating his commitment to the tech community and problem-solving skills. With a solid educational foundation and a diverse project portfolio, Mohit excels at navigating complex challenges and is well-equipped to contribute to dynamic software projects.

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Rayna McCann is a Registered Dietitian and Board Certified Specialist in Oncology Nutrition. She is a Registered Yoga Teacher and yoga4cancer certified. She received her BS in Nutrition at Penn State University and her MS from Stony Brook University. For work, Rayna wears many hats in the world of nutrition and worked for years in clinical settings focusing on oncology nutrition. She is also an Adjunct Professor and passionate about inspiring the future of dietitians. Throughout her career, she has received awards recognizing her dedication to patient safety and her contributions to improving malnutrition awareness. In 2022, Rayna was proud to accept the ‘Dietitian of the Year’ award through the Long Island Academy of Nutrition and Dietetics. Rayna has co-authored abstracts for poster presentations within the American Institute for Cancer Research conference, as well as, the Nutrition and Dietetics Food and Nutrition Conference Expo and subsequent publication. She has enjoyed authoring articles, including an article for The Cure magazine regarding Multiple Myeloma and nutrition. When Rayna is not participating in nutrition related activities, she is dedicated to dog rescue.

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